AI Article Synopsis
- Diet significantly influences brain functions, affecting things like cognitive processes, reproduction, and behavior, which can lead to either negative or positive health outcomes.
- The review emphasizes the role of Sirtuin1 (Sirt1), a key metabolic sensor in the brain, in maintaining health and its potential as a therapeutic target for certain diseases.
- It also explores how natural compounds, particularly polyphenols, may modulate the activity of Sirt1, linking energy balance with reproductive health.
Article Abstract
Diet deeply impacts brain functions like synaptic plasticity and cognitive processes, neuroendocrine functions, reproduction and behaviour, with detrimental or protective effects on neuronal physiology and therefore consequences for health. In this respect, the activity of metabolic sensors within the brain is critical for the maintenance of health status and represents a possible therapeutic target for some diseases. This review summarizes the main activity of Sirtuin1 (Sirt1), a metabolic sensor within the brain with a focus on the link between the central control of energy homeostasis and reproduction. The possible modulation of Sirt1 by natural phytochemical compounds like polyphenols is also discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908627 | PMC |
| http://dx.doi.org/10.3390/ijerph18031243 | DOI Listing |
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