Renal prostaglandin activity was assessed in children and adolescents with two forms of secondary (nephrogenic) arterial hypertension: vasorenal and chronic pyelonephritis-associated hypertension. Children with vasorenal hypertension showed renal PG changes, dependent on the duration of the disease. Positive correlation between arterial BP and PGF2 excretion, and negative correlation between PGE excretion and arterial BP are suggestive of the involvement of the renal PG system in vasorenal hypertension. Children and adolescents with arterial hypertension in the presence of chronic secondary pyelonephritis demonstrated a tendency to low excretion of both PG fractions, while their ratio remained unchanged. The absence of a correlation between urinary PG excretion and arterial BP indicates that renal prostaglandins make no significant pathogenetic contribution to this type of arterial hypertension.
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