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Variations of Serum Oxidative Stress Biomarkers under First-Line Antituberculosis Treatment: A Pilot Study. | LitMetric

AI Article Synopsis

  • * A study involved 30 newly diagnosed pulmonary TB patients who provided blood samples before and after 60 days of anti-TB treatment to assess changes in oxidative stress markers and antioxidant levels.
  • * Results indicated improvements in antioxidant enzymes like GSH, CAT, and SOD after treatment, while TBARS levels decreased, suggesting that monitoring oxidative stress could enhance understanding and management of TB.

Article Abstract

Tuberculosis (TB) is one of the highest infectious burdens worldwide, and pathogenesis is yet incompletely elucidated. Bacilli dissemination is due to poor antioxidant defense mechanisms and intensified oxidative stress. There are few recent studies that analyzed and compared free radicals or antioxidant status before and after anti-TB treatment. Hence, the present study underlines the need to identify oxidative stress as it could be a useful tool in TB monitorisation. Thirty newly diagnosed patients with pulmonary TB were included after signing an informed consent. Blood was collected before receiving first-line anti-tubercular therapy (T0) and after 60 days (T2). Spectrophotometric methods were used to quantify oxidative parameters (TBARS-thiobarbituric acid reactive species); enzymatic antioxidants such as SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase), and TAC (total antioxidant capacity); and non-enzymatic antioxidants such as GSH (reduced glutathione). A moderate positive correlation was found between GSH and TAC ( = 0.63, -value = 0.046) and GSH and SOD ( = 0.64, -value = 0.041) at T2. Increased values of GSH, CAT, and SOD were noted at T2 in comparison with T0, while GPx, TAC, and TBARS decreased at T2. A better monitorisation in TB could be based on oxidative stress and antioxidant status. Nevertheless, restoring redox host balance could reduce TB progression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916141PMC
http://dx.doi.org/10.3390/jpm11020112DOI Listing

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