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A Simple Sensitivity Analysis Method for Unmeasured Confounders via Linear Programming With Estimating Equation Constraints.
Stat Med
February 2025
Department of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan.
In estimating the average treatment effect in observational studies, the influence of confounders should be appropriately addressed. To this end, the propensity score is widely used. If the propensity scores are known for all the subjects, bias due to confounders can be adjusted by using the inverse probability weighting (IPW) by the propensity score.
View Article and Find Full Text PDFEstimation of Diagnostic Test Accuracy Without Gold Standards.
Stat Med
February 2025
Department of Biostatistics and Beijing International Center for Mathematical Research, Peking University, Beijing, China.
The ideal evaluation of diagnostic test performance requires a reference test that is free of errors. However, for many diseases, obtaining such a "gold standard" reference is either impossible or prohibitively expensive. Estimating test accuracy in the absence of a gold standard is therefore a significant challenge.
View Article and Find Full Text PDFSelf-Adaptive Quantum Kernel Principal Component Analysis for Compact Readout of Chemiresistive Sensor Arrays.
Adv Sci (Weinh)
January 2025
Data61, CSIRO, Clayton, VIC, 3168, Australia.
The rapid growth of Internet of Things (IoT) devices necessitates efficient data compression techniques to manage the vast amounts of data they generate. Chemiresistive sensor arrays (CSAs), a simple yet essential component in IoT systems, produce large datasets due to their simultaneous multi-sensor operations. Classical principal component analysis (cPCA), a widely used solution for dimensionality reduction, often struggles to preserve critical information in complex datasets.
View Article and Find Full Text PDFIs Weight Loss the Main Driver for A1C Improvement by Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists? A 2.5-Year Analysis in Real-World Clinical Practice.
J Diabetes
January 2025
Joslin Diabetes Center, Affiliated With Harvard Medical School, Boston, Massachusetts, USA.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are established treatment options for type 2 diabetes (T2D). In addition to their glycemic benefit, GLP-1 RAs also induce weight loss by suppressing appetite via hypothalamic pathways. However, it remains unclear whether weight reduction is the primary driver of glycemic improvement.
View Article and Find Full Text PDFComputational simulation of cranial soft tissue expansion on the cranium during early postnatal growth in humans.
J Anat
January 2025
Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS) and Human Anatomy Resource Centre (HARC), Education Directorate, University of Liverpool, Liverpool, UK.
The importance of interactions between neighbouring rapidly growing tissues of the head during development is recognised, yet this competition for space remains incompletely understood. The developing structures likely interact through a variety of mechanisms, including directly genetically programmed growth, and are mediated via physiological signalling that can be triggered by structural interactions. In this study, we aimed to investigate a different but related potential mechanism, that of simple mechanical plastic deformation of neighbouring structures of the head in response to soft tissue expansion during human postnatal ontogeny.
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