Protein-energy malnutrition is one of the leading causes of death for children under-five in developing countries and Kenya is no exception. These children rely on starchy weaning foods such as finger millet (), which have poor protein digestibility. Cowpea (, a locally available nutritious legume, could be an excellent complement to lysine-deficient millet diets. The present study thus aimed at innovatively improving protein digestibility of a baby weaning food, by evaluating the effect of malting on improved finger millet genotypes (U15, P224, KNE741, KNE629 and Snapping green) to enable selection of the best varieties with superior nutritional credential post process. Blending of selected finger millet with precooked cowpea flour followed the WHO recommended level at 10.32%, 21.26%, and 32.75% with 0% as control. Extractable phenols, condensed tannins, phytic acid, protein content, and protein digestibility were determined using recommended methods. Extractable phenol, condensed tannin, and phytate notably decreased by 44%, 47%, and 29% respectively after malting. Additionally, compositing with precooked cowpea increased protein content and protein digestibility in flour by about 6-39%. Cooking resulted in a 10% increase in protein digestibility in the complementary porridge. Malting of finger millet and compositing it with precooked cowpea has the potential to address PEM as it results in reduced anti-nutritional content with a concomitant improvement in protein digestibility of the baby weaning food.
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http://dx.doi.org/10.1007/s13197-020-04569-1 | DOI Listing |
Hepatol Commun
February 2025
Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background: Although bariatric and metabolic surgical methods, including duodenal-jejunal bypass (DJB), were shown to improve metabolic dysfunction-associated steatotic liver disease (MASLD) in clinical trials and experimental rodent models, their underlying mechanisms remain unclear. The present study therefore evaluated the therapeutic effects and mechanisms of action of DJB in rats with MASLD.
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J Appl Oral Sci
January 2025
University of Ibadan, College of Medicine, Department of Physiology, Ibadan, Nigeria.
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Universidade Federal da Grande Dourados - UFGD, Faculdade de Ciências Agrárias, Dourados, MS, Brasil.
The objective of this study was to evaluate the effects of three levels of lipids in the diet on growth, metabolism, and intestinal and hepatic histopathology in discus fish (Symphysodon aequifasciatus). Fish were stocked in quadruplicate in aquarium (50L) and were fed experimental diets containing three levels (3%, 10%, and 14%) of dietary lipids (LP). At the end of the trial, no significant differences in growth performance were observed.
View Article and Find Full Text PDFSci Transl Med
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Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91052 Erlangen, Germany.
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show that impaired fusion is sufficient to drive chronic intestinal inflammation.
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Animal Science Department, Federal University of Paraná, Palotina, PR, 85950-000, Brazil.
This study aimed to evaluate the effect of autolyzed yeast (obtained from culture of Saccharomyces cerevisiae in sugarcane derivatives) supplementation on diet digestibility, feeding behavior, levels of blood metabolites associated with protein and energy metabolism, and performance of Dorper × Santa Ines lambs finished in feedlot. Twenty-four non-castrated male lambs with an average age of 4 months and a body weight (BW) of 19.49 ± 3.
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