Coeliac disease, an autoimmune disease, is caused by ingestion of gluten in genetically susceptible individuals. The currently used modified-Marsh grading, used to assess mucosal injury, is fraught with interobserver and intraobserver variability. The aim is to reduce this variability by villous length morphometry. Our prospective study was conducted on newly diagnosed cases of coeliac disease that were assessed by serohaematological profile, and duodenal biopsies were evaluated by modified Marsh grading. Villous length was measured in Grades 2, 3a and 3b using an eyepiece graticule lens calibrated with a stage micrometer. Severity of mucosal injury in different Marsh grades was significantly correlated to mean villous length, elevation of mean IgA tTG and drop in haemoglobin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0049475521991350 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Caecal villi? A comparative histological and morphometric study of caecal and jejunal mucosa in adult rabbits.
Acta Vet Scand
September 2024
Department of Cell Biology, Histology and Embryology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Manastur Street no 3- 5, Cluj-Napoca, 400372, Romania.
Background: Rabbits are herbivores with a distinctive digestive strategy that differs significantly from other caecal fermenters (e.g., horses, guinea pigs) and ruminants.
View Article and Find Full Text PDFBioengineering approaches for patient-specific analysis of placenta structure and function.
Placenta
August 2024
Department of Biomedical Engineering, Washington University in St. Louis, St. Louis MO, USA; Center for Women's Health Engineering, Washington University in St. Louis, St. Louis MO, USA; Center for Regenerative Medicine, Washington University in St. Louis, St. Louis MO, USA; Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, St. Louis MO, USA. Electronic address:
Article Synopsis
- Fetal growth restriction (FGR) is the primary cause of perinatal mortality, linked to inadequate oxygen and nutrient exchange in the placenta.
- Novel methods like nanoindentation, optical coherence tomography, and ultrasound are used to assess the 3D structure, material properties, and blood flow of placental villi.
- Understanding these factors could help reveal how changes in placental microvasculature lead to FGR, potentially leading to better diagnosis and treatment options.
Multi-type maternal diabetes mellitus affects human placental villous geometric morphology: A three-dimensional imaging study.
Placenta
September 2024
School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China. Electronic address:
Introduction: Diabetes mellitus leads to maldevelopment of the villous morphology in the human placenta, disrupting the exchange of materials between the maternal and fetal compartments, consequently compromising fetal development. This study aims to explore how different types of diabetes mellitus affect human placental villous geometric morphology including branching numbers and sizes (length, diameter).
Methods: Here an optical coherence tomography (OCT)-based 3D imaging platform was utilized to capture 3D images of placental villi from different types of diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM).
Dietary Pediastrum boryanum microalgal extract improves growth, enhances immunity, and regulates immune-related genes in Nile tilapia.
BMC Vet Res
July 2024
Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Background: Identifying alternative sustainable feed sources with high nutritional values is crucial for the future of environmentally and socially responsible aquaculture. In this regard, microalgae have been proven to have positive effects on fish health, which overwhelmed our interest in this study.
Methods: Pediastrum boryanum (P.
Step-by-step protocol for isolating the entire repertoire of human first trimester placental cells.
Placenta
June 2024
Placental Development Group, Reproductive Biology Unit, Medical University of Vienna, Austria. Electronic address:
Correct placental development and function are essential for adapting the mother to the ongoing pregnancy and the wellbeing of the growing fetus; however, underlying processes are still poorly understood. Only limited structural and cellular placental features are shared among species hence requiring reliable human in-vitro models. Recently established trophoblast stem cell and organoid models significantly improved placental research; however, the human placenta constitutes a multi-cellular organ with tightly orchestrated, cellular and molecular networks between trophoblasts (TBs) and villous core cells (VCCs) vital for correct placentation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!