AI Article Synopsis
- The herpes simplex virus (HSV) is a significant human pathogen, and while acyclovir (ACV) is the standard treatment, resistance to it is on the rise.
- This study evaluated the antiherpetic effects of Cucumis melo sulfated pectin (SPCm), finding that it effectively reduced the virus's activity and had a high selectivity index against both ACV-sensitive and ACV-resistant strains of HSV-1.
- The results suggest that SPCm could be a promising alternative for controlling HSV infections due to its ability to inhibit viral protein and DNA synthesis.
Article Abstract
The herpes simplex virus, also known as HSV, is an important human pathogen. Acyclovir (ACV) is the first-line antiviral for the treatment of HSV infections; nevertheless HSV resistance to ACV has been increasingly reported and, therefore, search for alternative drugs have been encouraged. Herein, the effect of Cucumis melo sulfated pectin (SPCm) was evaluated in the HSV-1 infection. Pectin cytotoxicity and its antiherpetic action were determined by assays of MTT and plaque reduction, respectively. The SPCm concentration that reduced the cell viability by 50% (CC50) was 1440 μg/mL, while the concentration that reduced PFU in 50% (IC50) was 6 μg/mL against ACV-sensitive (KOS) strain and 12 μg/mL for ACV-resistant (AR-29) strain. The pectin showed high selectivity index (SI) for both viral strains. Therefore, we suggest that SPCm has been effective for HSV-1, strenghten by viral protein and DNA syntheses inhibition. In conclusion, we have found that SPCm is a promising alternative compound to control HSV infection.
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| http://dx.doi.org/10.1093/femsle/fnab013 | DOI Listing |
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