The aim of this study was to explore the effects of and gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for C3435T and T521C. C3435T and T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients The selected and polymorphism do not predict the risk of MTX resistance in low-risk GTN.
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| http://dx.doi.org/10.2217/pme-2020-0089 | DOI Listing |
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