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Background: Sub-Saharan Africa (SSA) has the highest sexually transmitted infection (STI) prevalence globally, but information about trends and geographic variation is limited by sparse aetiologic studies, particularly among men. This systematic review assessed chlamydia, gonorrhoea, and trichomoniasis prevalence by sex, sub-region, and year, and estimated male-to-female prevalence ratios for SSA.
Methods: We searched Embase, MEDLINE, Global Health, PubMed, and African Index Medicus for studies measuring STI prevalence among general populations from January 1, 2000, to September 17, 2024.
Doxycycline Postexposure Prophylaxis and Bacterial Sexually Transmitted Infections Among Individuals Using HIV Preexposure Prophylaxis.
JAMA Intern Med
January 2025
Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Article Synopsis
- Doxycycline postexposure prophylaxis (doxyPEP) effectively reduces the incidence of bacterial sexually transmitted infections (STIs) in those assigned male at birth, although practical data is limited.
- This study analyzed electronic health records of HIV PrEP users from Kaiser Permanente Northern California to assess the uptake of doxyPEP and its impact on STI rates before and after its initiation.
- Out of 11,551 HIV PrEP users, 19.5% received doxyPEP, with a notable percentage having an STI prior; findings suggest changes in STI positivity rates among those who started doxyPEP versus those who did not.
Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends.
JAMA Intern Med
January 2025
San Francisco Department of Public Health, San Francisco, California.
Article Synopsis
- The rising rates of sexually transmitted infections (STIs) have heightened health concerns, prompting research into doxycycline postexposure prophylaxis (doxyPEP) as a preventive strategy for bacterial STIs.
- A study was conducted in San Francisco to evaluate how the introduction of doxyPEP guidelines affected reported cases of chlamydia, gonorrhea, and early syphilis among men who have sex with men (MSM) and transgender women.
- Results revealed a significant decrease in STI cases among these populations after the implementation of doxyPEP guidelines, with chlamydia and early syphilis cases declining by 6.58% and 2.68% per month, respectively, compared to
One-year epidemiological patterns of respiratory pathogens across age, gender, and seasons in Chengdu during the post-COVID era.
Sci Rep
January 2025
Aba Teachers College, Wenchuan, Scichuan, China.
Respiratory tract infections caused by various pathogens remain a significant public health concern due to their high prevalence and potential for severe complications. This study systematically analyzed the epidemiological characteristics of six common respiratory pathogens-Chlamydia pneumoniae (CP), Mycoplasma pneumoniae (MP), Adenovirus (AdV), Influenza A virus (FluA), Influenza B virus (FluB), and Respiratory Syncytial Virus (RSV)-in patients from Sichuan Jinxin Xinan Women and Children's Hospital between April 2023 and March 2024. Throat swab samples were collected from a total of 22,717 individuals.
View Article and Find Full Text PDF[Determination of Gene Mutations Associated with Macrolide and Fluoroquinolone Resistance in Patients Infected with Mycoplasma genitalium].
Mikrobiyol Bul
October 2024
Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Türkiye.
A sexually transmitted bacterium, Mycoplasma genitalium has varying rates of reported resistance to macrolide and some fluoroquinolone group antimicrobials recommended for the treatment of its infections. It is currently recommended that the treatment of these must be planned according to macrolide resistance status. The aim of this study was to determine the presence of macrolide resistance associated mutations (MRM) and fluoroquinolone resistance associated mutations (QRM) in patients infected with M.
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