Heyde syndrome is a triad of bleeding colonic angiodysplasia, aortic stenosis, and acquired coagulopathy. It is most commonly seen in the elderly between 60-80 years of age. We present a case of Heyde syndrome presenting with severe anemia secondary to bleeding angiodysplasia or arteriovenous malformations (AVM) in the lower gastrointestinal (GI) tract.
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| http://dx.doi.org/10.7759/cureus.12551 | DOI Listing |
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Gastric Antral Vascular Ectasia Syndrome With Aortic Stenosis: A Twist on Heyde Syndrome?
J Med Cases
January 2025
Gastroenterology and Hepatology, St. Joseph's University Medical Center, Paterson, NJ, USA.
Heyde syndrome is a triad of aortic stenosis (AS), gastrointestinal (GI) bleeding from angiodysplasia, and acquired von Willebrand disease (vWD). It is hypothesized that stenotic aortic valves cleave von Willebrand factor (vWF) multimers, predisposing patients to bleeding from GI angiodysplasias. This hypothesis is supported by the observation that aortic valve replacement often leads to the resolution of GI bleeding.
View Article and Find Full Text PDFGastrointestinal Angiodysplasia Resolution After Transcatheter Aortic Valve Implantation.
JAMA Netw Open
October 2024
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Importance: Heyde syndrome is the cooccurrence of aortic stenosis and gastrointestinal bleeding secondary to vascular lesions, including angiodysplasias. Several studies have demonstrated cessation of gastrointestinal bleeding after transcatheter aortic valve implantation (TAVI), but the etiology and effects on vascular lesions are largely unknown.
Objective: To examine the associations of TAVI with gastrointestinal vascular lesions and identify factors associated with recovery among patients with iron deficiency anemia and severe aortic stenosis.
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Int J Mol Sci
October 2024
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach.
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Am J Case Rep
September 2024
Department of General Medicine, Saga University Hospital, Saga, Japan.
Article Synopsis
- Heyde syndrome consists of anemia, aortic valve stenosis, and acquired von Willebrand syndrome, yet it remains under-recognized in clinical settings.
- A 70-year-old woman with severe iron-deficiency anemia and aortic stenosis was diagnosed with Heyde syndrome after extensive testing that ruled out other bleeding sources.
- Aortic valve replacement surgery improved her anemia and symptoms, highlighting the need for awareness of Heyde syndrome in cases of unexplained anemia, particularly when associated with aortic stenosis.
Recent advances in the treatment of refractory gastrointestinal angiodysplasia.
United European Gastroenterol J
October 2024
Sorbonne University, Center for Digestive Endoscopy, Saint Antoine Hospital, AP HP, Paris, France.
Article Synopsis
- - Gastrointestinal angiodysplasia (GIA) is a prevalent, acquired vascular issue in the digestive tract, often leading to significant bleeding and requiring repeat treatments such as transfusions or endoscopies.
- - Recent studies focus on non-endoscopic options for treating refractory GIA, highlighting the effectiveness of aortic valve replacement in cases of Heyde syndrome and the use of anti-angiogenic drugs like Octreotide and Thalidomide.
- - Future advancements in understanding the underlying mechanisms of GIA could pave the way for the development of new, targeted treatments.
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