Searching for germline mutations in the gene among Polish patients with acute myeloid leukemia.

The aim of the study was the identification of constitutional mutations among AML patients. The study group included 100 patients of Polish origin, diagnosed with AML. 14 out of 100 AML patients had together 17 mutations, three of which were found to be germline changes. The difference in germline mutation frequency between study and control groups was not statistically significant ( = 0.193), but the odds ratio was 7.215. In all patients with germline mutations, chromosome 7 aberrations were found. The difference in the frequency of chromosome 7 aberrations between the group of patients with and without germline mutations was statistically significant ( = 0.008, OR = 73.00). We showed a higher frequency of germline mutations of in AML patients than in the control group, which confirms the role of these mutations in the development of AML, and an association of germline mutations with aberrations of chromosome 7.