AI Article Synopsis
- New pyrido[3,4-d]pyridazine derivatives were synthesized and tested for their antibacterial, antifungal, and antimycobacterial properties.
- Compound 10 and compound 12 showed the strongest antimycobacterial activities among the synthesized compounds.
- Despite some promising results, none of the compounds proved effective against the tested Gram-positive and Gram-negative bacteria or fungi.
Article Abstract
In this study, new pyrido[3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.
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