Facial micro expressions are brief, spontaneous, and crucial emotions deep inside the mind, reflecting the actual thoughts for that moment. Humans can cover their emotions on a large scale, but their actual intentions and emotions can be extracted at a micro-level. Micro expressions are organic when compared with macro expressions, posing a challenge to both humans, as well as machines, to identify. In recent years, detection of facial expressions are widely used in commercial complexes, hotels, restaurants, psychology, security, offices, and education institutes. The aim and motivation of this paper are to provide an end-to-end architecture that accurately detects the actual expressions at the micro-scale features. However, the main research is to provide an analysis of the specific parts that are crucial for detecting the micro expressions from a face. Many states of the art approaches have been trained on the micro facial expressions and compared with our proposed Lossless Attention Residual Network (LARNet) approach. However, the main research on this is to provide analysis on the specific parts that are crucial for detecting the micro expressions from a face. Many CNN-based approaches extracts the features at local level which digs much deeper into the face pixels. However, the spatial and temporal information extracted from the face is encoded in LARNet for a feature fusion extraction on specific crucial locations, such as nose, cheeks, mouth, and eyes regions. LARNet outperforms the state-of-the-art methods with a slight margin by accurately detecting facial micro expressions in real-time. Lastly, the proposed LARNet becomes accurate and better by training with more annotated data.
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http://dx.doi.org/10.3390/s21041098 | DOI Listing |
Cureus
December 2024
Department of Orthopaedics, University of Maryland, Baltimore, USA.
Background: Circulating tumor cells and clusters (CTC) from soft-tissue sarcoma (STS) that become entrapped in the lung can form micro-metastases and lead to pulmonary metastatic disease. Many patients with localized high-risk STS later develop metastases. Radiation is effective at reducing local recurrence by eradicating microscopic infiltration and satellites in the reactive zone surrounding the primary tumor.
View Article and Find Full Text PDFJ Taibah Univ Med Sci
February 2025
Shahid Beheshti University of Medical Sciences, Faculty of Dentistry, Department of Oral & Maxillofacial Pathology, Tehran, Iran.
Objective: This study was aimed at investigating the roles of podoplanin (PDPN) as a marker associated with malignant development, progression, and poor prognosis in oral leukoplakia and various forms of oral squamous cell carcinoma (OSCC), particularly in relation to the extent of invasion.
Methods: Immunohistochemical analysis of PDPN was conducted on 77 histologically confirmed, formalin-fixed, paraffin-embedded samples representing various degrees of OSCC invasion and dysplasia grades.
Results: The samples were analyzed with Fisher's exact test and the Kruskal-Wallis test.
Transplantation
January 2025
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh PA.
Reduced dependence on antirejection agents, improved long-term allograft survival, and induction of operational tolerance remain major unmet needs in organ transplantation due to the limitations of current immunosuppressive therapies. To address this challenge, investigators are exploring the therapeutic potential of adoptively transferred host- or donor-derived regulatory immune cells. Extracellular vesicles of endosomal origin (exosomes) secreted by these cells seem to be important contributors to their immunoregulatory properties.
View Article and Find Full Text PDFMol Neurobiol
January 2025
Guizhou Key Laboratory of Brain Science, Zunyi Medical University, Xinpu New District Campus No. 1 Street, Zunyi, 563000, China.
Previous studies have shown that astrocyte activation in the anterior cingulate cortex (ACC), accompanied by upregulation of the astrocyte marker S100 calcium binding protein B (S100B), contributes to comorbid anxiety in chronic inflammatory pain (CIP), but the exact downstream mechanism is still being explored. The receptor for advanced glycation end-products (RAGE) plays an important role in chronic pain and psychosis by recognizing ligands, including S100B. Therefore, we speculate that RAGE may be involved in astrocyte regulation of the comorbidity between CIP and anxiety by recognizing S100B.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
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