We describe a patient who developed multiple granulomatous skin lesions after Bacille de Calmette et Guérin (BCG) vaccination without significant effect by topical corticosteroid, followed by painless cystic tumors on the bilateral knees and hands and inflammatory changes on ophthalmologic examination. A functional mutation in 2 was detected by a genetic analysis, and he was diagnosed as sporadic Blau syndrome. Since 2 acts as a sensor for the BCG component, it is possible that BCG vaccination may trigger granuloma formation in Blau syndrome patients with such genetic background.
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| http://dx.doi.org/10.3390/children8020117 | DOI Listing |
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