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| http://dx.doi.org/10.1007/s41669-021-00258-7 | DOI Listing |
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Unlabelled: Cytoplasmic proteins must recruit to membranes to function in processes such as endocytosis and cell division. Many of these proteins recognize not only the chemical structure of the membrane lipids, but the curvature of the surface, binding more strongly to more highly curved surfaces, or 'curvature sensing'. Curvature sensing by amphipathic helices is known to vary with membrane bending rigidity, but changes to lipid composition can simultaneously alter membrane thickness, spontaneous curvature, and leaflet symmetry, thus far preventing a systematic characterization of lipid composition on such curvature sensing through either experiment or simulation.
View Article and Find Full Text PDFLiposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce a catheter-based endoscopic probe designed for multispectral, quantitative monitoring of light-triggered drug release. This tool utilizes red-light photosensitive porphyrin-phospholipid (PoP), which is encapsulated in liposome bilayers to enhance targeted drug delivery.
View Article and Find Full Text PDFGeny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes.
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Introduction: Accurate genotyping of Killer cell Immunoglobulin-like Receptor (KIR) genes plays a pivotal role in enhancing our understanding of innate immune responses, disease correlations, and the advancement of personalized medicine. However, due to the high variability of the KIR region and high level of sequence similarity among different KIR genes, the generic genotyping workflows are unable to accurately infer copy numbers and complete genotypes of individual KIR genes from next-generation sequencing data. Thus, specialized genotyping tools are needed to genotype this complex region.
View Article and Find Full Text PDFEnhancing Construction Safety Through Workplace Surveillance and Systematic Follow-Ups.
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View Article and Find Full Text PDFUse of a virtual phantom to assess the capability of a treatment planning system to perform magnetic resonance image distortion correction.
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Article Synopsis
- Treatment Planning Systems (TPS) are evaluated for their effectiveness in correcting distortions in Magnetic Resonance (MR) images using a virtual phantom and Control Points (CPs).
- The study involved creating distorted MR images and applying TPS, with findings showing that distortion caused median deviations of 1.8 mm, which were reduced to 0.6 mm after correction.
- Structural Similarity Metric (SSIM) tests indicated significant improvements in image quality, with the TPS successfully reducing distortions to levels acceptable for radiosurgery.
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