Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8 αβ T lymphocytes in untreated celiac disease.

We compared the αβ T-cell receptor repertoires of CD8 αβ intraepithelial lymphocytes from celiac disease patients and healthy subjects by single-cell sequencing. We demonstrate that the repertoires of untreated celiac disease patients were more polyclonal and more diverse than what was observed in both treated patients and healthy subjects.