Biomaterials function as an essential aspect of tissue engineering and have a profound impact on cell growth and subsequent tissue regeneration. The development of new biomaterials requires a potential platform to understand the host-biomaterial interaction, which is crucial for successful biomaterial implantation. Biomaterials analyzed in rodent models for in vivo research are cost-effective but tedious, and the practice has many technical difficulties. As an alternative, zebrafish provide an excellent biomaterial testing platform over the current rodent models. During growth and recovery, zebrafish bone morphogenesis shows a variety of inductive signals involved in the cycle that are close to those influencing differentiation of bone and cartilage in mammals, including humans. This platform is cheap, optically transparent, quick to change genes, and provides reliable reproducibility on short life cycles. Chitosan is a well-known biomaterial in the field of tissue engineering. In view of its documented use in bone regeneration, the biological characterization of chitosan-based bioactive materials in the zebrafish model has been featured in an outstanding note. We, therefore, outlined this review of the zebrafish as a potential in vivo research model for the rapid characterization of the biological properties of new biomaterials for bone tissue engineering applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2021.02.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Computational Pathology Detection of Hypoxia-Induced Morphological Changes in Breast Cancer.
Am J Pathol
December 2024
Department of Computer Science, Faculty of Engineering Sciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Understanding the tumor hypoxic microenvironment is crucial for grasping tumor biology, clinical progression, and treatment responses. This study presents a novel application of AI in computational histopathology to evaluate hypoxia in breast cancer. Weakly Supervised Deep Learning (WSDL) models can accurately detect morphological changes associated with hypoxia in routine Hematoxylin and Eosin (H&E) whole slide images (WSI).
View Article and Find Full Text PDFPreventive effect of sea bass protein-based high internal phase Pickering emulsion loaded with astaxanthin on DEHP-induced liver lipid metabolism disorder.
Int J Biol Macromol
December 2024
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China; Academy of Food Interdisciplinary Science, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, Liaoning, China; National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:
The present study was to investigate the effect of the astaxanthin high internal phase Pickering emulsion (H-AXT) on DEHP-induced liver lipid metabolism disorder and to demonstrate its possible protective mechanism. We have developed an antioxidant activity emulsion system to deliver astaxanthin into the liver to maximize its ability to protect the liver. In vitro, H-AXT intervention inhibited oxidative stress restored the level of mitochondrial membrane potential to 90 % of that of normal LO2 cells, and alleviated the imbalance of energy metabolism by protecting mitochondrial structure and function.
View Article and Find Full Text PDFAn overview of additive manufacturing strategies of enzyme-immobilized nanomaterials with application incatalysis and biomedicine.
Int J Biol Macromol
December 2024
School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea. Electronic address:
Meticulous and bespoke fabrication of structural materials with simple yet innovative outlines along with on-demand availability is the imperative aspiration for numerous fields. The alliance between nanotechnology and enzymes has led to the establishment of an inimitable and proficient class of materials. With the advancement in the field of additive manufacturing, the fabrication of some complex biological architects is achievable with similitude to the instinctive microenvironment of the biological tissue.
View Article and Find Full Text PDFAcrylamide/Alyssum campestre seed gum hydrogels enhanced with titanium carbide: Rheological insights for cardiac tissue engineering.
Int J Biol Macromol
December 2024
Department of Petroleum Engineering, Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran; Polymer Synthesis Technology, School of Chemical Engineering, Aalto University, Espoo, Finland.
This study investigates the use of acrylamide and Alyssum campestre seed gum (ACSG) to create hydrogel composites with enhanced electrical and mechanical properties by incorporating titanium carbide (TiC). The composites were analyzed through techniques such as FTIR, SEM, TEM, TGA, swelling, rheology, tensile, electrical conductivity, antibacterial, and MTT assays. XRD analysis showed that 0.
View Article and Find Full Text PDFConductive polyacrylamide/pullulan/ammonium sulfate hydrogels with high toughness, low-hysteresis and tissue-like modulus as flexible strain sensors.
Int J Biol Macromol
December 2024
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 210009, China.
Conductive hydrogels have great potential for applications in flexible wearable sensors due to the combination of biocompatibility, mechanical flexibility and electrical conductivity. However, constructing conductive hydrogels with high toughness, low hysteresis and skin-like modulus simultaneously remains challenging. In the present study, we prepared a tough and conductive polyacrylamide/pullulan/ammonium sulfate hydrogel with a semi-interpenetrating network.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!