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Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.
JAMA
November 2024
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Importance: Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population.
Objective: To assess the impact on neurological outcome of 2 different hemoglobin thresholds to guide red blood cell transfusions in patients with acute brain injury.
Importance: Fever is associated with worse outcomes in patients with stroke, but whether preventing fever improves outcomes is unclear.
Objective: To determine whether fever prevention after acute vascular brain injury is achievable and impacts functional outcome.
Design, Setting, And Participants: Open-label randomized clinical trial with blinded outcome assessment that enrolled 686 of 1176 planned critically ill patients with stroke at 43 intensive care units in 7 countries from March 2017 to April 2021 (last date of follow-up was May 12, 2022).
In Reply to the Letter to the Editor Regarding "Development of a Nomogram Model Based on Lactate-to-Albumin Ratio for Prognostic Prediction in Hospitalized Patients with Intracerebral Hemorrhage".
World Neurosurg
September 2024
School of Microelectronics and Data Science, Anhui University of Technology, Anhui, China; Anhui Provincial Joint Key Laboratory of Disciplines for Industrial Big Data Analysis and Intelligent Decision, Anhui, China. Electronic address:
Letter to the Editor Regarding "Development of a Nomogram Model Based on Lactate-to-Albumin Ratio for Prognostic Prediction in Hospitalized Patients with Intracerebral Hemorrhage".
World Neurosurg
September 2024
Department of Emergency and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Pudong, Shanghai, China. Electronic address:
In Reply to the Letter to the Editor Regarding "Endoscopic Surgery Versus Stereotactic Aspiration in Spontaneous Intracerebral Hemorrhage Treatment: A Systematic Review and Meta-Analysis".
World Neurosurg
September 2024
Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
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