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Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS).
Sci Rep
January 2025
Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Via Taramelli 3B, 27100, Pavia, Italy.
Perfluorinated compounds (PFAS) are well recognized toxic pollutants for humans, but if their effect is equally harmful for healthy and fragile people is unknown. Addressing this question represents a need for ensuring global health and wellbeing to all individuals in a world facing the progressive increase of aging and aging related diseases. This study aimed to evaluate the impact of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) exposure on development and skeletal phenotype using the osteogenesis imperfecta (OI) zebrafish model Chihuahua (Chi/+), carrying a dominant glycine substitution in the α1 chain of collagen I and their wild-type (WT) littermates.
View Article and Find Full Text PDFInvestigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging.
J Am Soc Mass Spectrom
January 2025
Maastricht MultiModal Molecular Imaging Institute (M4i), Division of Imaging Mass Spectrometry, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.
Drug toxicity during the development of candidate pharmaceuticals is the leading cause of discontinuation in preclinical drug discovery and development. Traditionally, the cause of the toxicity is often determined by histological examination, clinical pathology, and the detection of drugs and/or metabolites by liquid chromatography-mass spectrometry (LC-MS). While these techniques individually provide information on the pathological effects of the drug and the detection of metabolites, they cannot provide specific molecular spatial information without additional experiments.
View Article and Find Full Text PDFTiO-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application.
Int J Biol Macromol
January 2025
Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India; Functional Materials Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India.
Wounds that are not properly managed can cause complications. Prompt and proper care is essential, to prevent microbial infection. Growing interest in metal oxide nanoparticles (NPs) for innovative wound treatments targeting healing and microbial infections.
View Article and Find Full Text PDFSulfides as environmental stressors in Paracas Bay, Peru.
Mar Pollut Bull
January 2025
Facultad de Pesquería, Universidad Nacional Agraria La Molina, Av. La Molina S/N, La Molina, Lima 15024, Peru.
Paracas Bay, located in the Humboldt Current system, is a highly variable coastal environment where hypoxia (dissolved oxygen concentrations <2 mg L) has been reported as a persistent feature of bottom conditions. In addition to hypoxia, milky water events have been reported in the bay, most likely associated with the presence of sulfides (i.e.
View Article and Find Full Text PDFInvolvement of inorganic nitrogen species (NO (x = 2, 3)) in the degradation of organic contaminants in environmental waters via UV irradiation or chemical oxidation: A dual-edged approach.
Sci Total Environ
January 2025
Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Guangzhou, 510000, China.
OH-mediated advanced oxidation processes (AOPs) are widely used in wastewater treatment and drinking water purification. Recently, an increasing number of studies have indicated that common inorganic nitrogen ions can efficiently generate •OH under UV irradiation, demonstrating strong performance in the degradation of various contaminants. Conversely, the presence of inorganic nitrogen ions in UV or other oxidation processes dramatically increases the yield of toxic nitro (so)-aromatic products and the formation potential of nitrogenous disinfection by-products with high genotoxicity and cytotoxicity.
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