AI Article Synopsis
- A notable reduction in malonaldehyde and lipid peroxidation occurred in the livers of pregnant rats, influenced by substances like ascorbate, NADPH, and cumene hydroperoxide.
- Lipid peroxidation levels returned to normal within three days after giving birth.
- The decrease in lipid peroxidation during pregnancy is linked to lower phospholipid levels, reduced unsaturation of lipids, and increased antioxidant levels.
Article Abstract
A significant decrease in the hepatic malonaldehyde content and lipid peroxidation, induced by ascorbate, NADPH and cumene hydroperoxide, was observed during gestation in the rat. Lipid peroxidation tends to reach normal levels 3 days post partum. While a significant decrease in the lipid peroxidation of hepatic mitochondria was observed with ascorbate and NADPH, that of microsomes was affected by ascorbate and cumene hydroperoxide. The observed decrease in lipid peroxidation during pregnancy seems to be due to lesser phospholipid content, a lower degree of unsaturation in lipids, and an increase in the level of antioxidants.
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