AI Article Synopsis
- Parathyroid hormone and its fragment PTH-(1-34) are effective at relaxing coronary arteries, indicating they have a significant role in regulating blood flow.
- The study involved testing porcine coronary arteries in a controlled environment, where PTH-(1-34) was applied to precontracted arteries.
- Results demonstrated that PTH-(1-34) caused a noticeable dose-dependent relaxation, achieving up to 77% relaxation at certain concentrations, confirming its vasodilatory effect both in vivo and in vitro.
Article Abstract
Parathyroid hormone and it's aminoterminal 1-34 fragment, PTH-(1-34), are potent vasodilators of the coronary circulation in vivo. In order to fully characterize the mechanism of this effect on coronary vascular resistance, it was necessary to determine whether isolated coronary arteries would respond to the action of PTH-(1-34) in vitro. Porcine coronary arteries were cut into cylindrical segments, mounted in a muscle bath containing physiological salt solution, and precontracted with prostaglandin F2. After obtaining stable contractions, PTH-(1-34) was added over the dose range of 10(-10)-10(-7) M. The results showed that PTH-(1-34) produced a dose-dependent vasorelaxation of the coronary segments. A statistically significant relaxation was obtained at a concentration of 10(-10) M. The near-maximal relaxation was 77% with respect to control values. Thus, it has been shown for the first time that PTH-(1-34) relaxes precontracted coronary arteries in vitro, a finding which was consistent with the potent vasodilator action of the polypeptide hormone in vivo.
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