Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin's lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849780 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1837581 | DOI Listing |
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