Successful treatment of pyogenic ventriculitis caused by extensively drug-resistant with multi-route tigecycline: A case report.

Background: Pyogenic ventriculitis caused by extensively drug-resistant () is one of the most severe complications associated with craniotomy. However, limited therapeutic options exist for the treatment of ventriculitis due to the poor penetration rate of most antibiotics through the blood-brain barrier.

Case Summary: A 68-year-old male patient with severe traumatic brain injury developed pyogenic ventriculitis on postoperative day 24 caused by extensively drug-resistant susceptible to tigecycline only. Successful treatment was accomplished through multi-route administration of tigecycline, including intravenous combined with continuous ventricular irrigation plus intraventricular administration. The pus was cleared on the 3 day post-irrigation, and cerebrospinal fluid cultures were negative after 12 d.

Conclusion: Our findings suggest that multi-route administration of tigecycline can be a therapeutic option against pyogenic ventriculitis caused by extensively drug-resistant .