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Delayed onset serotonin syndrome in the setting of polypharmacy. | LitMetric

Delayed onset serotonin syndrome in the setting of polypharmacy.

J Community Hosp Intern Med Perspect

Department of Hematology and Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Published: January 2021

AI Article Synopsis

  • Serotonin syndrome is a serious condition that can be fatal if not recognized quickly, typically occurring within 4 to 13 hours after starting certain medications.
  • A case was presented where symptoms appeared after 48 hours, highlighting that delayed onset can occur, especially in patients on multiple medications (polypharmacy).
  • Healthcare providers should be vigilant for serotonin syndrome in elderly patients taking several drugs, as they may present with confusion, and delayed symptoms can lead to severe consequences.

Article Abstract

Serotonin syndrome is a rare but well-known condition that can be life-threatening if not diagnosed early. Onset is usually within 4 to 13 h of starting the offending medication. We present a case of delayed onset of serotonin syndrome that presented after 48 h. Polypharmacy played a role in causing the onset of symptoms. Clinicians should keep a high index of suspicion for serotonin syndrome when dealing with elderly confused patients who take multiple medications even when the onset is delayed or atypical because the outcome can be disastrous.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850348PMC
http://dx.doi.org/10.1080/20009666.2020.1834929DOI Listing

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