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Is Charles Bonnet Syndrome a Harbinger of Neurocognitive Disorder With Lewy Bodies? A Clinical Conundrum.
J Psychiatr Pract
January 2025
Department of Psychiatry, Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Charles Bonnet syndrome (CBS) is a clinical condition in which patients with visual impairment experience visual hallucinations (VH) in the presence of clear consciousness. It typically occurs in elderly people and confuses clinicians with multiple differential diagnoses due to VH, which can be present in a variety of clinical conditions ranging from psychosis to neurocognitive disorders (eg, neurocognitive disorder with Lewy bodies). In the latter, the concomitant presence of cognitive decline and parkinsonism aids the diagnosis.
View Article and Find Full Text PDFMyelin oligodendrocyte glycoprotein antibody-associated disease/paediatric multiple sclerosis overlap: a diagnostic conundrum.
BMJ Case Rep
January 2025
Neurology, National Center for Child Health and Development, Setagaya-ku, Japan.
While advancements in the classification of acquired demyelinating syndromes have significantly benefited children with this condition, some cases present with overlapping features, posing diagnostic challenges. We describe an Asian girl of early childhood age with acute visual loss. Examination revealed right optic neuritis, left optic nerve atrophy and demyelinating lesions in the juxtacortical brain parenchyma.
View Article and Find Full Text PDFThe complexities in the differential diagnosis of restless legs syndrome (Willis-Ekbom disease).
Expert Rev Neurother
January 2025
Parkinson's Foundation Centre of Excellence, King's College Hospital, London, UK.
Introduction: We present a literature review on the clinical conundrums surrounding the differential diagnosis of restless legs syndrome (RLS, Willis-Ekbom disease), as well as conditions that can mimic RLS. An extensive literature search showed that secondary causes of RLS ranged from commonly recognized causes, such as iron deficiency anemia, to less widely noted causes, such as rheumatoid disorders and hypothyroidism. There is a controversial association with Parkinson's disease, essential tremor, and RLS, whereby RLS is proposed as a prodromal feature.
View Article and Find Full Text PDFAntithrombotic therapy in patients with chronic coronary syndrome: a focus on the 2024 European Society of Cardiology guidelines.
Eur Heart J Acute Cardiovasc Care
December 2024
Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Via Tesserete, 48, 6900 Lugano, Switzerland.
Antithrombotic therapy represents the mainstay of the pharmacological treatment in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). The optimal choice, combination, and duration of antithrombotic therapy represent still a clinical conundrum requiring a critical assessment of patient comorbidities, clinical presentation, and PCI features. The 2024 European Society of Cardiology (ESC) guidelines for the management of patients with CCS have been recently published encompassing new and revised recommendations on antithrombotic therapy.
View Article and Find Full Text PDFAn Osteopathic Approach to Foot Drop: A Case Report of Posterior Fibular Head.
Cureus
October 2024
Physical Medicine and Rehabilitation, New York Presbyterian Queens Hospital, New York, USA.
Chronic foot drop can present a diagnostic challenge, often leading to extensive medical evaluations without definitive resolution. We report a case of a 42-year-old female with an elusive cause of foot drop, a complex and engaging case that required extensive medical evaluations. The patient's complex medical history includes kidney infections, migraine headaches, and irritable bowel syndrome, treated with conventional medications and osteopathic manipulative techniques.
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