AI Article Synopsis
- Natural products, including plant extracts and essential oils, show potential as anti-SARS-CoV agents, which could lead to new drug development against coronaviruses.
- The study reviewed recent research on medicinal plants and identified 29 species and over 300 compounds, with flavonoids and terpenes emerging as promising candidates.
- Emphasizing the importance of ethnopharmacology, the paper advocates for combined in silico and in vitro methods to enhance antiviral research and discovery.
Article Abstract
Background: Natural products are useful agents for the discovery of new lead- compounds and effective drugs to combat coronaviruses (CoV).
Objective: The present work provides an overview of natural substances, plant extracts, and essential oils as potential anti-SARS-CoV agents. In addition, this work evaluates their drug-like properties which are essential in the selection of compounds in order to accelerate the drug development process.
Methods: The search was carried out using PubMed, ScienceDirect and SciFinder. Articles addressing plant-based natural products as potential SARS-CoV or SARS-CoV-2 agents within the last seventeen years were analyzed and selected. The descriptors for Chemometrics analysis were obtained in alvaDesc and the principal component analysis (PCA) was carried out in SIMCA version 13.0.
Results: Based on in vitro assays and computational analyses, this review covers twentynine medicinal plant species and more than 300 isolated substances as potential anti-coronavirus agents. Among them, flavonoids and terpenes are the most promising compound classes. In silico analyses of drug-like properties corroborate these findings and indicate promising candidates for in vitro and in vivo studies to validate their activity.
Conclusion: This paper highlights the role of ethnopharmacology in drug discovery and suggests the use of integrative (in silico/ in vitro) and chemocentric approaches to strengthen current studies and guide future research in the field of antiviral agents.
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| http://dx.doi.org/10.2174/0929867328666210125113938 | DOI Listing |
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