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| http://dx.doi.org/10.1016/j.jinf.2021.02.002 | DOI Listing |
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Spatial Organization of Macrophages in CTL Rich Hepatocellular Carcinoma Influences CTL Antitumor Activity.
Cancer Immunol Res
January 2025
Sun Yat-sen University, Guangzhou, China.
Despite the pivotal role of cytotoxic T lymphocytes (CTLs) in anti-tumor immunity, a substantial proportion of CTL-rich hepatocellular carcinoma (HCC) patients experience early relapse or immunotherapy resistance. However, spatial immune variations impacting the heterogeneous clinical outcomes of CTL-rich HCCs remain poorly understood. Here, we compared the single-cell and spatial landscapes of 20 CTL-rich HCCs with distinct prognoses using multiplexed in situ staining and validated the prognostic value of myeloid spatial patterns in a cohort of 386 patients.
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JAMA Netw Open
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Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, Massachusetts.
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View Article and Find Full Text PDFCost-Effectiveness of Breast Cancer Screening Using Digital Mammography in Canada.
JAMA Netw Open
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Medical Oncology, The Ottawa Hospital Cancer Centre, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
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Artificial Intelligence-Enhanced Electrocardiography for Prediction of Incident Hypertension.
JAMA Cardiol
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National Heart and Lung Institute, Imperial College London, United Kingdom.
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View Article and Find Full Text PDFTen-Year Change in Visual Function and Incidence of Visual Impairment in Highly Myopic Children and Adults.
Invest Ophthalmol Vis Sci
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State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
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