AI Article Synopsis
- The study examined calbindin D-28K expression in the pineal bodies of Mongolian gerbils and rats, finding no significant calbindin-positive cells in gerbils but numerous in rats.
- In rats, calbindin-positive cells were likely pinealocytes located near capillaries, suggesting a role in calcium transport and regulation.
- The absence of calbindin in gerbils implies their pinealocytes may struggle to manage intracellular calcium, potentially leading to the development of acervuli (calcified structures).
Article Abstract
Immunocytochemical reaction for demonstration of calbindin D-28K has been performed in superficial pineal bodies of the Mongolian gerbil (Meriones unguiculatus) and the rat. Whereas in the Mongolian gerbil there were no clearly expressed calbindin immunoreactive cells, these were numerous in the rat pineal body. Here the calbindin-positive cells - probably pinealocytes - were disposed along capillaries. In view of the role of calbindin in binding and transporting calcium and regulating its intracellular levels, the absence of this protein in the gerbil pineal body has been interpreted as signifying the inability of pinealocytes to eliminate intracellular calcium with possible consequent formation of acervuli.
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