AI Article Synopsis
- The vascular network is formed and maintained through vasculogenesis and angiogenesis, which require precise cellular processes influenced by small Rho GTPases and the DOCK protein family.
- Evidence suggests that DOCK proteins, typically linked to neuronal development, also play crucial roles in regulating vascular growth and development through various signaling pathways (like CXCR4, VEGF, and PI3K).
- The review explores current insights into DOCK proteins' functions in vascular development and their potential link to human vascular diseases and related dysfunctions.
Article Abstract
The vascular network is established and maintained through the processes of vasculogenesis and angiogenesis, which are tightly regulated during embryonic and postnatal life. The formation of a functional vasculature requires critical cellular mechanisms, such as cell migration, proliferation and adhesion, which are dependent on the activity of small Rho GTPases, controlled in part by the dedicator of cytokinesis (DOCK) protein family. Whilst the majority of DOCK proteins are associated with neuronal development, a growing body of evidence has indicated that members of the DOCK family may have key functions in the control of vasculogenic and angiogenic processes. This is supported by the involvement of several angiogenic signalling pathways, including chemokine receptor type 4 (CXCR4), vascular endothelial growth factor (VEGF) and phosphatidylinositol 3-kinase (PI3K), in the regulation of specific DOCK proteins. This review summarises recent progress in understanding the respective roles of DOCK family proteins during vascular development. We focus on existing in vivo and in vitro models and known human disease phenotypes and highlight potential mechanisms of DOCK protein dysfunction in the pathogenesis of vascular disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292242 | PMC |
| http://dx.doi.org/10.1007/s10456-021-09768-8 | DOI Listing |
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