Bioengineered neural tissues help advance our understanding of neurodevelopment, regeneration, and neural disease; however, it remains unclear whether they can replicate higher-order functions including cognition. Building upon technical achievements in the fields of biomaterials, tissue engineering, and cell biology, investigators have generated an assortment of artificial brain structures and cocultured circuits. Though they have displayed basic electrochemical signaling, their capacities to generate minimal patterns of information processing suggestive of high-order cognitive analogues have not yet been explored. Here, we review the current state of neural tissue engineering and consider the possibility of a study of cognition in vitro. We adopt a practical definition of minimal cognition, anticipate problems of measurement, and discuss solutions toward a study of cognition in a dish.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946736 | PMC |
| http://dx.doi.org/10.1016/j.tics.2021.01.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of a Virtual Reality Game With Leap Motion Controller on Brain Activity Related to Attentional Function in Healthy Adults - A Pilot EEG Study.
Cureus
October 2024
Department of Occupational Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, JPN.
Objective Virtual reality (VR) games with the Leap Motion Controller (LMC) are used in clinical practice for cognitive rehabilitation to improve attentional function. However, the effects of VR games using the LMC on brain activity related to attentional function have not yet been elucidated. This study aimed to elucidate the effects of a VR game with the LMC on brain activity related to attentional function.
View Article and Find Full Text PDFHuman iPSCs from Aged Donors Retain Their Mitochondrial Aging Signature.
Int J Mol Sci
October 2024
Research Cluster Molecular and Cognitive Neurosciences, University of Basel, 4002 Basel, Switzerland.
Aging represents the leading risk factor for developing neurodegenerative disorders. One of the nine hallmarks of aging is mitochondrial dysfunction. Age-related mitochondrial alterations have been shown to affect mitochondrial energy metabolism, reduction-oxidation homeostasis, and mitochondrial dynamics.
View Article and Find Full Text PDFA framework for translating tauopathy therapeutics: Drug discovery to clinical trials.
Alzheimers Dement
November 2024
Rainwater Charitable Foundation, Fort Worth, Texas, USA.
The tauopathies are defined by pathological tau protein aggregates within a spectrum of clinically heterogeneous neurodegenerative diseases. The primary tauopathies meet the definition of rare diseases in the United States. There is no approved treatment for primary tauopathies.
View Article and Find Full Text PDFHow pupils of different ages perceive menus denoting metaphorical and metonymic expressions: Insights from eye-tracking.
Acta Psychol (Amst)
September 2024
Center for the Cognitive Science of Language, Beijing Culture and Language University, No.15 Xueyuan Road Haidian District, Beijing, China.
The "embodied" position on language comprehension proposes that metaphor or metonymy understanding can be represented in a distributed network based on previous sensorimotor experience. The current study attempted to investigate how children understood metaphor and metonymy in the context of daily diet that provided rich sensory experience for children. We implemented an eye-tracking experiment where a 2 × 2 × 2 mixed design was employed.
View Article and Find Full Text PDFSpectral degradation and carrier sentences increase age-related temporal processing deficits in a cue-specific manner.
J Acoust Soc Am
June 2024
Department of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742, USA.
Advancing age is associated with decreased sensitivity to temporal cues in word segments, particularly when target words follow non-informative carrier sentences or are spectrally degraded (e.g., vocoded to simulate cochlear-implant stimulation).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!