Deer antler velvet (DAV) extract is important in stimulating the growth of skin and hair cells. The aim of this study was to develop DAV extract-loaded niosomes (NIs) and microspicules (MS) serum for effective hair growth. Bioactivities of DAV extract on human dermal papilla cells were studied. To develop protein delivery, NIs were prepared to entrap DAV extract and then loaded into MS serum (NI serum MS). Physicochemical properties and in vitro skin permeations were evaluated. The formulations were applied on human scalp and relative efficacies were evaluated. DAV extract at 2,000 µg/ml significantly enhanced cell proliferation and aggregation. DAV extract-loaded NI exhibited nanovesicle, narrow size distribution and negative surface charge. The vesicles were able to load into MS serum and showed significantly highest macromolecular protein permeation through the skin, with deposition into the deepest skin layer compared with other formulations. Applying the serum on human scalp for 14 and 30 days significantly enhanced hair elongation and melanin content, with increased skin hydration and decreased the erythema index, thereby promoting hair growth without skin irritation. NI serum MS containing DAV extract played an important role to deliver biomacromolecular protein through the skin and hair follicles, leading to effective hair growth.
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