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http://dx.doi.org/10.1007/s11302-021-09768-9 | DOI Listing |
Purinergic Signal
June 2021
Department of Pharmaceutical Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy.
Cell Tissue Res
June 2021
Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, University College London Medical School, Royal Free Campus, London, UK.
This tribute article presents selected immunocytochemical and transmission electron microscope data on the location of ATP-gated P2X receptor in the rat brain, as studied in the 1990s in Prof G. Burnstock's laboratory at University College London. There are examples of immuno-ultrastructural findings and introductory information about pre- and post-synaptic location of P2X receptors in the rat cerebellum and endocrine hypothalamus to support the concept of purinergic transmission in the central nervous system.
View Article and Find Full Text PDFPurinergic Signal
March 2021
Pharmacology Department, Punjab University College of Pharmacy, University of the Punjab, Lahore, 54000, Pakistan.
Purinergic Signal
March 2021
Institute of Clinical Pharmacology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
Biochem Pharmacol
May 2021
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, via Balzaretti, 9, 20133 Milan, Italy. Electronic address:
Fundamental progresses have been made in pain research with a comprehensive understanding of the neuronal pathways which convey painful sensations from the periphery and viscera to the central nervous system and of the descending modulating pathways. Nevertheless, many patients still suffer from various painful conditions, which are often associated to other primary pathologies, and get no or poor relief from available painkillers. Thus, the interest of many researchers has concentrated on new and promising cellular targets and biochemical pathways.
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