Purpose: To evaluate the clinical effect of Nd:YAP laser in periodontal regeneration surgery.
Methods: Four weeks after primary periodontal treatment, 48 patients, 60 teeth with bone defect and probing depth(PD) ≥6 mm, bleeding on probing (BOP)(+), were randomly divided into two groups. Patients in the experimental group were treated with Nd:YAP laser combined with periodontal regeneration surgery, while patients in the control group were treated with conventional periodontal regeneration surgery alone. Visual analogue scale(VAS) score was used to evaluate the pain degree of patients 24 hours and 3 days after surgery. The probing depth(PD) and clinical attachment loss(CAL) were examined before and 6 months after surgery, and preoperative and postoperative X-ray images of the two groups were observed and compared. SPSS 26.0 software package was used for statistical analysis.
Results: Twenty-four hours and 3 days after surgery, the pain in the experimental group was significantly less than that in the control group (P<0.001), and PD and CAL levels in the two groups were significantly lower 6 months after surgery than before surgery (P<0.001). There was no significant difference in PD and CAL between the two groups before surgery, and the difference was statistically significant 6 months after surgery(P<0.001). X-ray images showed different degrees of new bone formation in alveolar bone defects in the two groups 6 months after surgery.
Conclusions: The application of Nd:YAP laser in periodontal regeneration surgery can reduce postoperative pain and improve the surgical efficacy.
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J Periodontal Res
January 2025
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Aim: This study aimed to evaluate and compare the results of combination therapy involving bone grafting and two different resorbable collagen membranes in 1-, 2- and 3-wall infrabony defects.
Methods: A total of 174 patients with infrabony defects (≥ 7 mm periodontal probing depth) were randomized to receive deproteinized bovine bone mineral (DBBM) with either a native porcine non-crosslinked collagen membrane (N-CM, control, n = 87) or a novel porcine crosslinked collagen membrane (C-CM, test, n = 87). Clinical parameters, including periodontal probing depth (PPD), clinical attachment level (CAL), and gingival recession (GR), were recorded at baseline, 12 weeks, and 24 weeks.
Int Dent J
January 2025
Department of Microbiology, University of Dhaka, Dhaka, Dhaka, Bangladesh.
Hydroxyapatite nanoparticles (HANPs) are becoming increasingly crucial in dental implant applications as they are highly compatible with biological systems, actively support biological processes, and closely resemble bone minerals. This review covers the latest progress in how HANPs are made, studied, and used in dentistry. It looks at critical methods for creating HANPs, such as sol-gel, microwave hydrothermal synthesis, and biomimetic approaches, and how they affect the particles' size, structure, and activity.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Nantes Université, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, F-44000 Nantes, France.
Inflammation significantly influences cellular communication in the oral environment, impacting tissue repair and regeneration. This study explores the role of small extracellular vesicles (sEVs) derived from lipopolysaccharide (LPS)-treated stem cells from the apical papilla (SCAP) in modulating macrophage polarization and osteoblast differentiation. SCAPs were treated with LPS for 24 h, and sEVs from untreated (SCAP-sEVs) and LPS-treated SCAP (LPS-SCAP-sEVs) were isolated via ultracentrifugation and characterized using transmission electron microscopy, Western blot, and Tunable Resistive Pulse Sensing.
View Article and Find Full Text PDFDent Mater
January 2025
Department of Cariology, Restorative Sciences and Endodontics, University of Michigan, School of Dentistry, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Regeneration of the multiple tissues and interfaces in the periodontal complex necessitates multidisciplinary evaluation to establish structure/function relationships. This article, an initiative of the Academy of Dental Materials, provides guidance for performing chemical, structural, and mechanical characterization of materials for periodontal tissue regeneration, and outlines important recommendations on methods of testing bioactivity, biocompatibility, and antimicrobial properties of biomaterials/scaffolds for periodontal tissue engineering. First, we briefly summarize periodontal tissue engineering fabrication methods.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Institute of Stomatology & Research Center of Dental Esthetics and Biomechanics, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian 350002, China. Electronic address:
Alveolar bone defects caused by inflammation or trauma jeopardize patients' oral functions. Guided bone regeneration (GBR) is widely used in repairing periodontal tissue, with barrier membranes play a crucial role in preserving the bone regeneration space. In this study, an injectable dual-crosslinked hydrogel was developed to improve the existing barrier membranes in flexibility and functionality.
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