Objective: To assess the complications of dual placement of an intrathecal baclofen (ITB) pump and a ventriculoperitoneal shunt (VPS) in people with severe brain injury.
Design: Case series.
Setting: Referral center, ambulatory, and hospitalized care.
Participants: Referred sample (N=9) composed of 5 men and 4 women with severe brain injuries (5 traumatic brain injuries, 3 subarachnoid hemorrhages, 1 intracerebral hemorrhage) and a mean disease duration of 6±4.5 years (range, 0.5-11.4y).
Intervention: Both systems (ie, an ITB device and a VPS system) were implanted in all participants.
Main Outcome Measures: We assessed the number and type of complications that occurred after implantation of the second system, as well as subsequent interventions.
Results: The ITB delivery system was implanted after the VPS system in 5 patients (ITB group), and the VPS system was the second implanted system in 4 groups (VPS group). Seven complications occurred in 7 patients after implantation of the second system, 4 in the ITB group and 3 in the VPS group. Three of the complications were drug-related, 2 were procedure-related, and 2 were device-related. The complication occurred within 4 days after implantation of the second system in 6 patients.
Conclusions: Complications are frequent in patients who undergo implantation of both an ITB delivery device and a VPS system. Drug-related complications were more common. Complications occurred more often when an ITB device was implanted as the second system. The critical period is the first 4 days.
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http://dx.doi.org/10.1016/j.arrct.2020.100082 | DOI Listing |
Elife
January 2025
Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble new fibrils. Endogenous collagen production was not required for fibrillogenesis if exogenous collagen was available, but the circadian-regulated vacuolar protein sorting (VPS) 33b and collagen-binding integrin α11 subunit were crucial to fibrillogenesis.
View Article and Find Full Text PDFJ Ethnobiol Ethnomed
January 2025
Department of Biology, College of Natural and Computational Science, Arba Minch University, Arba Minch, Ethiopia.
Background: Homegardens (HGs) are well-time-honored traditional land use systems in small plots of land with purposely designed intricate structure and a mixture of planted vascular plants (VPs) for different purposes. Hence, the present study was initiated to investigate the ethnobotanical information of vascular plants of homegardens and their use, conservation and management practice by the people of Dawuro in southwestern Ethiopia.
Methods: A total of 162 farmer informants were selected and interviewed within a distance of < 2 km, 2-4 km and > 4 km between the natural forest and homegardens, and 0.
J Clin Neurosci
January 2025
Division of Neurosurgery, Department of Surgery, National University Hospital, National University Health System, Singapore.
Ventriculoperitoneal shunt (VPS) insertion is a neurosurgical procedure done routinely for managing hydrocephalus. However, the technique of shunt insertion remains controversial. In this study, we retrospectively compared the accuracy of shunt placement using ultrasound (US) guidance to freehand insertion.
View Article and Find Full Text PDFInfect Dis Clin Microbiol
December 2024
Department of Anesthesiology and Critical Care Unit, Başkent University School of Medicine, Ankara, Türkiye.
Background: The objective of this study was to investigate the barriers to follow-up of women with cervical lesions suspicious of cancer who were ineligible for primary-level treatment and needed, but did not receive, hospital-level care in Loreto, Peru.
Methods: In-depth, semi-structured interviews were conducted with 18 HPV-positive women requiring hospital-level follow-up care for cervical lesions suspicious of cancer but for whom there was no documentation of completion of treatment. After thematically analyzing these patient interviews, interview findings were presented to seven doctors and five nurse-midwives at both the hospital and the primary levels for comments and suggestions regarding barriers to treatment.
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