Objectives: Due to the infectiousness of COVID-19, the mobility of individuals has sharply decreased, both in response to government policy and self-protection. This analysis seeks to understand how mobility reductions reduce the spread of the coronavirus (SAR-CoV-2), using readily available data sources.
Methods: Mobility data from Google is correlated with estimates of the effective reproduction rate, which is a measure of viral infectiousness (Google, 2020). The Google mobility data provides estimates of reductions in mobility, for six types of trips and activities. for US states are downloaded from an on-line platform that derives daily estimates based on data from the Covid Tracking Project (Wissel et al., 2020; Systrom et al., 2020). Fixed effects models are estimated relating mean and 80% upper level credible interval estimates to changes in mobility and a time-trend value and with both 7-day and 14-day lags.
Results: All mobility variables are correlated with median and the upper level credible interval of . Staying at home is effective at reducing . Time spent at parks has a small positive effect, while other activities all have larger positive effects. The time trend is negative suggesting increases in self-protective behavior. Predictions suggest that returning to baseline levels of activity for retail, transit, and workplaces, will increase above 1.0, but not for other activities. Mobility reductions of about 20-40% are needed to achieve an below 1.0 (for the upper level 80% credible interval) and even larger reductions to achieve an below 0.7.
Conclusions: Policy makers need to be cautious with encouraging return to normal mobility behavior, especially returns to workplaces, transit, and retail locations. Activity at parks appears to not increase as much. This research also demonstrates the value of using on-line data sources to conduct rapid policy-relevant analysis of emerging issues.
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http://dx.doi.org/10.1016/j.jth.2021.101016 | DOI Listing |
mBio
January 2025
Department of Medical and Molecular Genetics and Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
causes the genital ulcer disease chancroid and cutaneous ulcers in children. To study its pathogenesis, we developed a human challenge model in which we infect the skin on the upper arm of human volunteers with to the pustular stage of disease. The model has been used to define lesional architecture, describe the immune infiltrate into the infected sites using flow cytometry, and explore the molecular basis of the immune response using bulk RNA-seq.
View Article and Find Full Text PDFJ Craniofac Surg
January 2025
Department of Plastic Surgery, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital).
Introduction: The strategy of adipose component transplantation has been proposed and widely used in both reconstructive and aesthetic surgery. However, there is no uniform standard for the preparation of component fat, and the volume calculation of liposuction and injection in clinical applications is mostly based on experience. This study aims to analyze the volume of component fat obtained during clinical series.
View Article and Find Full Text PDFmSphere
January 2025
WOAH Reference Laboratory for CWD, Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Gimcheon, South Korea.
Chronic wasting disease (CWD) is a highly contagious prion disease occurring in free-ranging and farmed cervids. CWD continues to spread uncontrolled across North America, and cases continue to be detected almost every year in the Republic of Korea. CWD-infected animals contaminate the soil by releasing infectious prions through their excreta, and shed prions accumulate and remain infectious in the soil for years.
View Article and Find Full Text PDFJ Brachial Plex Peripher Nerve Inj
January 2025
School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.
View Article and Find Full Text PDFFront Pediatr
January 2025
The Ritchie Centre, Hudson Institute of Medical Research, Clayton VIC, Australia.
Introduction: As airway liquid is cleared into lung interstitial tissue after birth, the chest wall must expand to accommodate this liquid and the incoming air. We examined the effect of applying external positive and negative pressures to the chest wall on lung aeration in near-term rabbit kittens at risk of developing respiratory distress.
Methods: Rabbit kittens (30 days; term ∼31 days) were randomised into and groups.
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