AI Article Synopsis
- Acute viral hepatitis can lead to various complications, including fulminant liver failure and sometimes acute pancreatitis, though this is rare in individuals with benign hepatitis who aren't experiencing liver failure.
- The exact cause of pancreatitis linked to hepatitis is not fully understood, but possible explanations include immune reactions against pancreatic cells, swelling in the ampulla of Vater, and liver enzyme release.
- It’s crucial for healthcare providers to consider acute pancreatitis when a patient with viral hepatitis presents with severe abdominal pain, as failing to identify it can worsen the patient's outcome, as demonstrated in a case involving a young man with hepatitis E infection complicated by pancreatitis.
Article Abstract
Acute viral hepatitis has been associated with several extrahepatic complications. Fulminant liver failure secondary to acute viral hepatitis may be complicated by acute pancreatitis. However, in the setting of benign viral hepatitis, in the absence of liver failure, association of pancreatitis is uncommon, that too in an otherwise immunocompetent individual. The exact mechanism of hepatitis-related pancreatitis remains elusive. Proposed mechanisms include immune-mediated injury against infected pancreatic acinar cells, oedema of the ampulla of Vater and release of lysosomal enzymes from the liver. A high index of clinical suspicion is needed in any case of viral hepatitis with severe abdominal pain to recognise acute pancreatitis as a possible complication, which may increase both morbidity and mortality if unrecognised. Herein, we report a case of a young man presenting with acute viral hepatitis due to hepatitis E infection, complicated by acute pancreatitis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868235 | PMC |
| http://dx.doi.org/10.1136/bcr-2020-239684 | DOI Listing |
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