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http://dx.doi.org/10.1136/postgradmedj-2020-139672 | DOI Listing |
Genomics Proteomics Bioinformatics
January 2025
Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.
Tumor-specific antigens, also known as neoantigens, have potential utility in anti-cancer immunotherapy, including immune checkpoint blockade (ICB), neoantigen-specific T cell receptor-engineered T (TCR-T), chimeric antigen receptor T (CAR-T), and therapeutic cancer vaccines (TCVs). After recognizing presented neoantigens, the immune system becomes activated and triggers the death of tumor cells. Neoantigens may be derived from multiple origins, including somatic mutations (single nucleotide variants, insertion/deletions, and gene fusions), circular RNAs, alternative splicing, RNA editing, and polymorphic microbiome.
View Article and Find Full Text PDFF1000Res
January 2025
Grupo de investigación "Sostenibilidad", Universidad Cesar Vallejo, Los Olivos, Lima, Peru.
Entrepreneurship involves the actions of designing, launching and managing a business that initially starts small and grows along with the human structure that integrates it. The health crisis caused by coronavirus disease 2019 (COVID-19) had negative effects on health, but also on business; many ventures had to innovate in order to survive in this uncertain environment. Peru is a country located in Latin America, recognized for its high levels of entrepreneurial self-efficacy, so this scooping review sought to identify the experiences of innovation in entrepreneurship in times of COVID-19 in that country.
View Article and Find Full Text PDFEnviron Sci Technol Lett
January 2025
PSI Center for Energy and Environmental Sciences, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Oxidative potential (OP) is increasingly recognized as a more health-relevant metric than particulate matter (PM) mass concentration because of its response to varying chemical compositions. Given the limited research on the OP of complex combustion aerosols, the effects of aging processes on their OP remain underexplored. We used online instruments to track the evolution of OP [via dithiothreitol (DTT) assays] during the aging of wood burning and coal combustion emissions by hydroxyl-radical-driven photooxidation and dark ozonolysis.
View Article and Find Full Text PDFACS Environ Au
January 2025
Department of Geography, Hong Kong Baptist University, Hong Kong SAR 999077, China.
Brown carbon (BrC) has been recognized as an important light-absorbing carbonaceous aerosol, yet understanding of its influence on regional climate and air quality has been lacking, mainly due to the ignorance of regional coupled meteorology-chemistry models. Besides, assumptions about its emissions in previous explorations might cause large uncertainties in estimates. Here, we implemented a BrC module into the WRF-Chem model that considers source-dependent absorption and avoids uncertainties caused by assumptions about emission intensities.
View Article and Find Full Text PDFHealth Aff Sch
January 2025
Health Policy Center, Urban Institute, 2201 General Taylor Street, New Orleans, LA 70115, United States.
We develop and illustrate a framework to trace value from social determinants of health (SDOH) interventions across 4 dimensions: health, cost and quality, engagement, and equity. To provide context, we begin by estimating the societal value lost to premature deaths from homelessness and food insecurity, using recent longitudinal methods that offer greater precision. We then apply the value tracing framework to 2 example interventions: permanent supportive housing for chronically homeless people and medically tailored meals for dual eligibles.
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