AI Article Synopsis
- The study aimed to see if non-diabetic cats with left ventricular hypertrophy (LVH) and previously diagnosed hypertrophic cardiomyopathy (HCM) have high levels of insulin-like growth factor 1 (IGF-1).
- A review of blood samples from 60 non-diabetic cats revealed that 6.7% had IGF-1 levels over 1000 ng/ml, while none in the control group (16 healthy cats) had similar levels.
- The findings suggest that a small number of non-diabetic HCM cats may experience elevated IGF-1, which could indicate a condition known as feline hypersomatotropism (fHS), highlighting the need for more research on this topic.
Article Abstract
Objectives: The aim of the study was to document whether a proportion of non-diabetic cats with left ventricular hypertrophy (LVH) previously diagnosed with hypertrophic cardiomyopathy (HCM) have elevated circulating insulin-like growth factor 1 (IGF-1) concentrations.
Methods: A retrospective analysis of residual blood samples obtained at the time of echocardiographic diagnosis of HCM from a population of 60 non-diabetic cats were analysed for circulating IGF-1 concentrations using a validated radioimmunoassay and compared with a control group of 16 apparently healthy cats without LVH. Clinical and echocardiographic data for cats with an IGF-1 level >1000 ng/ml were compared with those with an IGF-1 level <800 ng/ml.
Results: In total, 6.7% (95% confidence interval 1.8-16.2%) of cats with HCM had an IGF-1 level >1000 ng/ml. The prevalence of an IGF-1 level >1000 ng/ml in the control group was zero.
Conclusions And Relevance: A small proportion of non-diabetic cats previously diagnosed with HCM had an IGF-1 concentration at a level that has been associated with feline hypersomatotropism (fHS) in the diabetic cat population. Further prospective research is required to confirm or refute the presence of fHS in non-diabetic cats with LVH and increased IGF-1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197129 | PMC |
| http://dx.doi.org/10.1177/1098612X20987995 | DOI Listing |
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