AI Article Synopsis
- Palbociclib is a CDK 4/6 inhibitor showing effectiveness in treating HR+ and HER-2- breast cancer when used with endocrine therapy.
- A case study is presented of a woman with recurrent metastatic breast adenocarcinoma who had complete resolution of skin lesions after just one cycle of Palbociclib.
- This case is noteworthy as it demonstrates the rarity of rapid response to Palbociclib and emphasizes the need to consider skin metastasis in patients with a history of breast cancer.
Article Abstract
Palbociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor. Palbociclib combined with endocrine therapy has shown promising results in hormone-receptor-positive (HR+) and human epidermal growth factor receptor-negative (HER-2-) breast cancer progression. We present a case of a woman with a history of infiltrating lobular cancer of the left breast, status post modified radical mastectomy 6 years prior, presenting with nodular erythematous lesions on the left arm and back. Histopathological examination confirmed the diagnosis of recurrent metastatic breast adenocarcinoma. She had complete resolution of cutaneous metastasis with 1 cycle of Palbociclib. We believe our case is unique as the resolution of cutaneous metastasis with 1 cycle of single-agent Palbociclib is rare. Furthermore, it highlights the importance of considering cutaneous metastasis as a possibility in patients with prior history of primary internal malignancy.
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| http://dx.doi.org/10.1159/000512499 | DOI Listing |
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