AI Article Synopsis
- Cryptococcus gattii is a fungus known to cause cryptococcosis, particularly in healthy individuals living in tropical and subtropical areas.
- A unique case of cryptococcosis was documented in an HIV-negative patient from Ivory Coast who was infected by a specific strain of Cryptococcus gattii, with significant genetic analysis revealing its uniqueness.
- Successful treatment was administered with fluconazole, marking a significant finding as this case represents the first recorded incident of C. gattii sensu stricto in a non-HIV patient in Ivory Coast.
Article Abstract
Introduction: Cryptococcus gattii species complex is endemic to tropical and subtropical regions and is described as a causative agent of cryptococcosis in immunocompetent individuals.
Case Presentation: We describe the first case of cryptococcosis in a HIV-negative patient from Ivory Coast infected by Cryptococcus gattii sensu stricto VGI. Isolates were recovered from cerebrospinal fluid (CSF) prior to systemic antifungal treatment up to 42 days after detection of the presence of yeasts in the CSF. Eighteen isolates were recovered, genetic diversity and antifungal susceptibility analyses were performed. All the isolates belonged to the Cryptococcus gattii sensu stricto (B;VGI) and were identified as a new sequence type (ST) 553 by Multilocus Sequence Typing (MLST) analyses. Susceptibility testing showed that all the strains had a wild-type phenotype for fluconazole, amphotericin B and flucytosine. Treatment with fluconazole (1200mg/day) was initiated with success.
Conclusion: This is the first case report of the presence of C. gattii sensu stricto VGI in a HIV-negative ivorian patient and the second report of the presence of species from the C. gattii complex species in this country.
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| http://dx.doi.org/10.1016/j.mycmed.2021.101113 | DOI Listing |
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