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Powder flow from an intermediate bulk container - Discharge predictions and experimental evaluation. | LitMetric

Powder flow from an intermediate bulk container - Discharge predictions and experimental evaluation.

Int J Pharm

Early Product Development and Manufacturing, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca Gothenburg, Sweden. Electronic address:

Published: March 2021

AI Article Synopsis

  • Intermediate Bulk Containers (IBCs) are essential for dispensing and transferring powders in tablet manufacturing, with their discharge process significantly impacting product quality.
  • Various flow behavior characterization techniques were employed to analyze selected excipients, including the Hausner ratio, Carr's index, and several flow tests.
  • A simple discharge rate model based on gravity and aerodynamic drag proved effective, with the small-scale Erweka flow test yielding the best predictions for full-scale IBC discharge experiments.

Article Abstract

Powders are usually dispensed, blended, and transferred between different manufacturing steps in so-called Intermediate Bulk Containers (IBCs), and discharge from an IBC plays a critical role in the ability to manufacture high-quality tablets. To better understand IBC discharge, the flow behavior of selected excipients was comprehensively characterized using a number of techniques including the Hausner ratio/Carr's index, Erweka flow test, FlowPro flow test, shear test and wall friction test as well as FT4 powder rheometer experiments. Jenike's hopper design methodology was then used to predict the minimum non-arching outlet diameter and the mode of flow. Furthermore, the discharge rate from an IBC was predicted using a simple model that takes into account gravity and aerodynamic drag. The predictions were experimentally verified by measuring the discharge rate from a 20 L IBC using five commonly-used excipients. The small-scale Erweka flow test provided the best prediction of the full-scale IBC discharge experiment. Furthermore, a simple model that relied only on the particle size of the material and the diameter of the discharge opening was found to predict the IBC discharge rate remarkably well.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2021.120309DOI Listing

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