Potential of Raman spectroscopy in facilitating pharmaceutical formulations development - An AI perspective.

Drug development is time-consuming and inherently possesses a high failure rate. Pharmaceutical formulation development is the bridge that links a new chemical entity (NCE) to pre-clinical and clinical trials, and has a high impact on the efficacy and safety of the final drug product. Further, the time required for this process is escalating as formulation techniques are becoming more complicated due to the rising demands for drug products with better efficacy and patient compliance, as well as the inherent difficulties of addressing the unfavorable properties of NCEs such as low water solubility. The advent of artificial intelligence (AI) provides possibilities to accelerate the drug development process. In this review, we first examine applications of AI methods in different types of pharmaceutical formulations and formulation techniques. Moreover, as availability of data is the engine for the advancement of AI, we then suggest a potential way (i.e. applying Raman spectroscopy) for faster high-quality data gathering from formulations. Raman techniques have the capability of analyzing the composition and distribution of components and the physicochemical properties thereof within formulations, which are prominent factors governing drug dissolution profiles and subsequently bioavailability. Thus, useful information can be obtained bridging formulation development to the final product quality.