AI Article Synopsis
- A new method was developed to create eco-friendly, single-site catalysts using amino acids and common metals, specifically for asymmetric catalysis.
- The process involves embedding amino acids in a metal-organic framework (MOF) and then adding iron to create highly effective catalysts that achieve over 99% enantioselectivity in various reactions.
- The MOF-Fe catalyst demonstrated impressive durability, being reused over 15 times with consistent performance, significantly outperforming traditional homogeneous catalysts due to its unique single-site design.
Article Abstract
We report a strategy to develop heterogeneous single-site enantioselective catalysts based on naturally occurring amino acids and earth-abundant metals for eco-friendly asymmetric catalysis. The grafting of amino acids within the pores of a metal-organic framework (MOF), followed by post-synthetic metalation with iron precursor, affords highly active and enantioselective (>99 % ee for 10 examples) catalysts for hydrosilylation and hydroboration of carbonyl compounds. Impressively, the MOF-Fe catalyst displayed high turnover numbers of up to 10 000 and was recycled and reused more than 15 times without diminishing the enantioselectivity. MOF-Fe displayed much higher activity and enantioselectivity than its homogeneous control catalyst, likely due to the formation of robust single-site catalyst in the MOF through site-isolation.
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| http://dx.doi.org/10.1002/anie.202100643 | DOI Listing |
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