Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
PseudoSorter: A self-supervised spike sorting approach applied to reveal Tau-induced reductions in neuronal activity.
Sci Adv
March 2025
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Microelectrode arrays (MEAs) permit recordings with high electrode counts, thus generating complex datasets that would benefit from precise neuronal spike sorting for meaningful data extraction. Nevertheless, conventional spike sorting methods face limitations in recognizing diverse spike shapes. Here, we introduce PseudoSorter, which uses self-supervised learning techniques, a density-based pseudolabeling strategy, and an iterative fine-tuning process to enhance spike sorting accuracy.
View Article and Find Full Text PDFInhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy.
Sci Adv
March 2025
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Duchenne muscular dystrophy (DMD) is a devastating X-linked disorder caused by dystrophin gene mutations. Despite recent advances in understanding the disease etiology and applying emerging treatment methodologies, glucocorticoid derivatives remain the only general therapeutic option that can slow disease development. However, the precise molecular mechanism of glucocorticoid action remains unclear, and there is still need for additional remedies to complement the treatment.
View Article and Find Full Text PDFAmeliorative potential of Populus alba leaf powder against hexaflumuron exposure in Nile tilapia: immune-antioxidant, biochemical, histological, and transcriptomic analysis.
Fish Physiol Biochem
March 2025
Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Egypt.
Contamination of the aquatic bodies with pesticides is a serious issue that hinders the aquaculture industry worldwide. Preventing aquatic pollution is a challenge, and finding eco-friendly strategies could help to overcome such a problem. Herein, we studied the antagonistic potential of dietary fortification of white poplar (Populus alba; PA) leaf powder against chronic hexaflumuron (HX) toxicity in Nile tilapia (Oreochromis niloticus).
View Article and Find Full Text PDFMolecular aspects of heat stress sensing in land plants.
Plant J
March 2025
Department of Botany, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.
Heat stress impacts all aspects of life, from evolution to global food security. Therefore, it becomes essential to understand how plants respond to heat stress, especially in the context of climate change. The heat stress response (HSR) involves three main components: sensing, signal transduction, and cellular reprogramming.
View Article and Find Full Text PDFMolecular insights into odorant recognition: Rotational and docking studies of 3-methylcyclopentane-1,2-dione and its monohydrate.
J Chem Phys
March 2025
College of Food Science, Southwest University, Tiansheng Rd. 2, 400715 Chongqing, China.
The binding behavior of 3-methylcyclopentane-1,2-dione, a cyclic α-diketone with a caramel-like aroma, was investigated to elucidate molecular mechanisms of olfactory recognition. Using Fourier-transform microwave spectroscopy complemented with quantum chemical calculations, the structures of 3-methylcyclopentane-1,2-dione and its monohydrate were determined, revealing the preferred conformation of the monomer and structural changes upon complexation with water. Intramolecular hydrogen bond weakening was observed, indicating significant rearrangements, as further supported by non-covalent interaction and quantum theory analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!