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The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer.
Pol J Pathol
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Department of Pulmonary Medicine, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Mutations in the KRAS gene in non-small cell lung cancer (NSCLC) are common drivers. Gene expression and mutation data of NSCLC were collected from the TCGA dataset. DEGs between KRAS mutations and wild type were identified, and enrichment analysis was performed.
View Article and Find Full Text PDFMetabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.
BMC Genomics
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, California, USA.
Background: The resurgence of Anopheles funestus, a dominant vector of human malaria in western Kenya was partly attributed to insecticide resistance. However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An.
View Article and Find Full Text PDFAcute arsenic exposure induces cyto-genotoxicity and histological alterations in Labeo rohita.
J Trace Elem Med Biol
January 2025
Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan. Electronic address:
Background: Arsenic emerges as most potent hazardous element ranked as number one in ATSDR (Agency for Toxic Substances and Disease Registry) list, can easily accumulate in fish, transported to humans via consumption and affect humans and aquatic organisms. Considering above, current experiment designed to evaluate cyto-genotoxicity and histological alterations induced by arsenic in Labeo rohita used as an animal model.
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Expressional Alternation of 5α-Reductase Type I, P450 Aromatase, and Androgen and Estrogen Receptors in the Mouse Testis Induced by the Lipectomy of the Epididymal Fat at Different Postnatal Ages.
Dev Reprod
December 2024
Department of Biochemistry and Molecular Biology, College of Medicine, Eulji University, Daejeon 34824, Korea.
The epididymal fat is required for the maintenance of normal spermatogenesis, and the lipectomy of epididymal fat at different postnatal age results in disrupted expression patterns of several testicular steroidogenic enzymes. The current research examined the effect of epididymal fat lipectomy at different postnatal ages on expression of cytochrome 5α-reductase I, cytochrome P450 aromatase, androgen receptor (AR), and estrogen receptors (ER) α and β in the mouse testis after 2 weeks of the lipectomy. The lipectomy of epididymal fat at 2 months of postnatal age resulted in significant increases of expression levels of cytochrome 5α-reductase I, cytochrome P450 aromatase, AR, and ER α and β.
View Article and Find Full Text PDFSingle-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis.
Front Cell Infect Microbiol
January 2025
Laboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.
Background: The vitamin D pathway contributes to the microbicidal activity of macrophages against infection. In addition to induction of this pathway, interferon-gamma (IFNγ), interleukin (IL)-15, and IL32γ are part of a network of pro-inflammatory cytokines. The aim of this study was to evaluate single-nucleotide polymorphisms (SNPs) in the components of the vitamin D pathway and associated cytokine genes that could be related to resistance or susceptibility to American tegumentary leishmaniasis (ATL).
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