Aspirin for Deep-Venous Thrombosis Prophylaxis After Anterior Cruciate Ligament Reconstruction.

Sean C McIntire Ethan M Bernstein Trevor M Tompane Avery M Briggs William J Ferris Christopher H Renninger Lucas S McDonald Andrew P Hurvitz

Mil Med

Department of Orthopaedic Surgery, Naval Medical Center San Diego, San Diego, CA 92134, USA.

Published: July 2021

This study aimed to determine if taking full-dose aspirin daily after ACL reconstruction could lower the risk of developing symptomatic deep-venous thrombosis (DVT).* -
In a review of 1,233 patients, 10 experienced postoperative symptomatic DVT, with seven from no medication and three from aspirin use, showing no significant difference in risk.* -
The findings indicated that aspirin did not significantly reduce DVT risk, while tobacco use was associated with a higher likelihood of developing DVT post-surgery.*

Aim: To evaluate whether a daily full-dose aspirin regimen after anterior cruciate ligament (ACL) reconstruction reduces the risk of postoperative symptomatic deep-venous thrombosis (DVT).

Materials And Methods: Single-center retrospective cohort study of patients who underwent ACL reconstruction from 2007 to 2016. One thousand two hundred thirty-three patients met inclusion criteria: 821 patients received no chemoprophylaxis and 412 patients received daily full-dose aspirin.

Results: A total of 10 patients, seven receiving no chemoprophylaxis and three using aspirin, sustained a postoperative symptomatic DVT. Calculated adjusted odds ratio for symptomatic postoperative DVT for aspirin versus no chemoprophylaxis was 0.928 (95% CI 0.237-3.629, P value = 0.91). Odds ratio for symptomatic postoperative DVT occurrence among tobacco users versus non-tobacco users was 3.76 (95% CI 1.077-13.124, P = 0.04).

Conclusions: No statistically significant difference was observed in postoperative symptomatic DVT after ACL reconstruction in those who received full-dose aspirin chemoprophylaxis versus those with no chemoprophylaxis. Additionally, there was a significantly increased risk of postoperative symptomatic DVT with tobacco use.

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http://dx.doi.org/10.1093/milmed/usab025	DOI Listing

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