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Completion of neuronal remodeling prompts myelination along developing motor axon branches. | LitMetric

AI Article Synopsis

  • * Research indicates that local axon remodeling can delay the onset of myelination and the formation of nodes, while glial differentiation doesn't influence the remodeling process.
  • * The delay in myelination is not due to a lack of necessary materials but is triggered by the increased transport of signaling molecules like neuregulin, which is regulated by the maturation of the cytoskeleton.

Article Abstract

Neuronal remodeling and myelination are two fundamental processes during neurodevelopment. How they influence each other remains largely unknown, even though their coordinated execution is critical for circuit function and often disrupted in neuropsychiatric disorders. It is unclear whether myelination stabilizes axon branches during remodeling or whether ongoing remodeling delays myelination. By modulating synaptic transmission, cytoskeletal dynamics, and axonal transport in mouse motor axons, we show that local axon remodeling delays myelination onset and node formation. Conversely, glial differentiation does not determine the outcome of axon remodeling. Delayed myelination is not due to a limited supply of structural components of the axon-glial unit but rather is triggered by increased transport of signaling factors that initiate myelination, such as neuregulin. Further, transport of promyelinating signals is regulated via local cytoskeletal maturation related to activity-dependent competition. Our study reveals an axon branch-specific fine-tuning mechanism that locally coordinates axon remodeling and myelination.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868780PMC
http://dx.doi.org/10.1083/jcb.201911114DOI Listing

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