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Muscle Loss During First-Line Chemotherapy Impairs Survival in Advanced Pancreatic Cancer Despite Adapted Physical Activity.
J Cachexia Sarcopenia Muscle
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Department of Medical Oncology, Lille University Hospital, Lille, France.
Background: Advanced pancreatic ductal adenocarcinoma (aPDAC) is often accompanied by significant muscle mass loss, contributing to poor prognosis. SarcAPACaP, an ancillary study of the GERCOR-APACaP phase III trial, evaluated the role of adapted physical activity (APA) in aPDAC Western patients receiving first-line chemotherapy. The study aimed to assess (1) the potential impact of computed tomography (CT)-quantified muscle mass before and during treatments on health-related quality of life (HRQoL) and overall survival (OS) and (2) the role of APA in mitigating muscle mass loss.
View Article and Find Full Text PDFKnee loading and joint pain during daily activities in people with knee osteoarthritis: A systematic review and meta-analysis.
Clin Biomech (Bristol)
January 2025
Department for Health, University of Bath, Bath, UK; Centre for the Analysis of Motion, Entertainment Research and Applications (CAMERA), University of Bath, Bath, UK.
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Service of Orthopaedics and Traumatology, Department of Surgery EOC Lugano Switzerland.
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View Article and Find Full Text PDFIntegrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer.
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Adv Exp Med Biol
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Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
"A Guide to Breast Cancer Research: From Cells and Molecular Mechanisms to Therapy" is designed as a comprehensive reference for early career investigators and postgraduate students. This book aims to provide a broad overview of contemporary breast cancer research. It covers key areas including development and cancer, metastasis and immunology, subtypes, signalling, therapy, and resistance.
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