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Estimating inflammatory risk in atherosclerotic cardiovascular disease: plaque over plasma?
Eur Heart J Cardiovasc Imaging
December 2024
Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Inflammation is an important driver of disease in the context of atherosclerosis, and several landmark trials have shown that targeting inflammatory pathways can reduce cardiovascular event rates. However, the high cost and potentially serious adverse effects of anti-inflammatory therapies necessitate more precise patient selection. Traditional biomarkers of inflammation, such as high-sensitivity C-reactive protein (hsCRP), show an association with cardiovascular risk on a population level, but do not have specificity for local plaque inflammation.
View Article and Find Full Text PDFThe potential advantages of F sodium fluoride positron emission tomography-computed tomography for clinical staging and management planning in patients with nasopharyngeal carcinoma.
Quant Imaging Med Surg
May 2024
Department of Nuclear Medicine (PET-CT Center), Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Background: The staging and treatment planning of nasopharyngeal carcinoma (NPC) face challenges due to limited sensitivity of conventional imaging. F-sodium fluoride (F-NaF) positron emission tomography-computed tomography (PET/CT) offers potential advantages in detecting early bone involvement. This retrospective cohort study aimed to assess the potential advantage of F-NaF PET/CT for clinical staging and management planning in patients with NPC and to compare F-NaF PET/CT findings with those of conventional imaging modalities.
View Article and Find Full Text PDFInput function and modeling for determining bone metabolic flux using [ F] sodium fluoride PET imaging: A step-by-step guide.
Med Phys
April 2023
Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London, UK.
Studies of skeletal metabolism using measurements of bone metabolic flux (K ) obtained with [ F] sodium fluoride ([ F]NaF) positron emission tomography (PET) scans have been used in clinical research for the last 30 years. The technique has proven useful as an imaging biomarker in trials of novel drug treatments for osteoporosis and investigating other metabolic bone diseases, including chronic kidney disease mineral and bone disorder. It has also been shown to be valuable in metastatic bone disease in breast cancer patients and may have potential in other cancer types, such as prostate cancer, to assess early bone fracture risk.
View Article and Find Full Text PDFThe Efficacy of Trabecular Titanium Cages to Induce Reparative Bone Activity after Lumbar Arthrodesis Studied through the 18f-Naf PET/CT Scan: Observational Clinical In-Vivo Study.
Diagnostics (Basel)
September 2022
Neurosurgery Unit, ICCS Città Studi, 20131 Milan, Italy.
Titanium trabecular cages (TTCs) are emerging implants designed to achieve immediate and long-term spinal fixation with early osseointegration. However, a clear radiological and clinical demonstration of their efficacy has not yet been obtained. The purpose of this study was to evaluate the reactive bone activity of adjacent plates after insertion of custom-made titanium trabecular cages for the lumbar interbody with positron emission tomography (PET)/computed tomography (CT) 18F sodium fluoride (18F-NaF).
View Article and Find Full Text PDFMicrocalcification and Thoracic Aortopathy: A Window Into Disease Severity.
Arterioscler Thromb Vasc Biol
August 2022
Department of Radiology, Division of Cardiology, Cardiovascular Translational Lab at the Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada (H.S., J.A.L., S.L.S.).
Background: Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established.
Methods: One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects.
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