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| http://dx.doi.org/10.1093/gbe/evaa266 | DOI Listing |
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Climate change and epigenetics: Unraveling the role of methylation in response to thermal instability in the Antarctic plant Colobanthus quitensis.
Physiol Plant
January 2025
Centro de Ecología Integrativa (CEI), Instituto de Ciencias Biológicas, Universidad de Talca, Talca, Chile.
Low temperatures are one of the critical conditions affecting the performance and distribution of plants. Exposure to cooling results in the reprogramming of gene expression, which in turn would be mediated by epigenetic regulation. Antarctica is known as one of the most severe ecosystems, but several climate models predict an increase in average temperature, which may positively impact the development of Antarctic plants; however, under warmer temperatures, plants' vulnerability to damages from low-temperature events increases.
View Article and Find Full Text PDFALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner.
Mol Cancer
January 2025
Department of Gastric Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.
The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a significant role in tumorigenesis and cancer progression. However, the detailed biological functions and underlying mechanisms of m6A regulation in gastric cancer (GC) are poorly understood. Our research revealed that the m6A demethylase ALKBH5 was markedly downregulated in GC tissues, which was associated with poor patient prognosis.
View Article and Find Full Text PDFAcquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos.
Epigenetics Chromatin
January 2025
Department of Maternal‑Fetal Biology, National Center for Child Health and Development, Tokyo, 157‑8535, Japan.
Background: DNA methylation plays a crucial role in mammalian development. While methylome changes acquired in the parental genomes are believed to be erased by epigenetic reprogramming, accumulating evidence suggests that methylome changes in sperm caused by environmental factors are involved in the disease phenotypes of the offspring. These findings imply that acquired sperm methylome changes are transferred to the embryo after epigenetic reprogramming.
View Article and Find Full Text PDFPerspectives and opportunities in forensic human, animal, and plant integrative genomics in the Pangenome era.
Forensic Sci Int
January 2025
Institute of Rare Diseases, West China Hospital of Sichuan University, Sichuan University, Chengdu 610000, China; Center for Archaeological Science, Sichuan University, Chengdu 610000, China; Department of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing 400331, China. Electronic address:
The Human Pangenome Reference Consortium, the Chinese Pangenome Consortium, and other plant and animal pangenome projects have announced the completion of pilot work aimed at constructing high-quality, haplotype-resolved reference graph genomes representative of global ethno-linguistically different populations or different plant and animal species. These graph-based, gapless pangenome references, which are enriched in terms of genomic diversity, completeness, and contiguity, have the potential for enhancing long-read sequencing (LRS)-based genomic research, as well as improving mappability and variant genotyping on traditional short-read sequencing platforms. We comprehensively discuss the advancements in pangenome-based genomic integrative genomic discoveries across forensic-related species (humans, animals, and plants) and summarize their applications in variant identification and forensic genomics, epigenetics, transcriptomics, and microbiome research.
View Article and Find Full Text PDFEvolutionary lineage-specific genomic imprinting at the ZNF791 locus.
PLoS Genet
January 2025
Department of Animal Sciences, The Ohio State University, Columbus, Ohio, United States of America.
Genomic imprinting is an epigenetic process that results in parent-of-origin effects on mammalian development and growth. Research on genomic imprinting in domesticated animals has lagged due to a primary focus on orthologs of mouse and human imprinted genes. This emphasis has limited the discovery of imprinted genes specific to livestock.
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